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The Hampton Inn Port Huron hotel is conveniently located near the International Blue Water Bridge Border Crossing and are easily accessible to I-94, I-69 and M-25 in Michigan. Port Huron is located in close proximity to Flint, Detroit, London Ontario, and Sarnia Ontario. Port Huron has stunning waterways and diverse annual events that make it a year-round tourist destination. With abundant attractions, a high standard of living, and convenient location, Port Huron, Michigan is a great place to visit and the Hampton Inn Port Huron hotel is a great place to stay. Local Corporations.