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The Hampton Inn and Suites St. Louis-Edwardsville hotel is conveniently located on I-270; in the Glen Carbon area which offers the best of Southwestern Illinois. Whether you have come to enjoy the areas increasingly famous bike and walking trails, visit Southern Illinois University at Edwardsville 3 miles up the road, or catch a sporting event in St. Louis....there is always something to do in the Glen Carbon area. Whether you choose one of our standard rooms or one of our spacious king studio suites, the comfortable and familiar amenities you have come to expect from Hampton are ready and waiting for you. Here at the Hampton Inn and Suites St.