In the UCLA Department of Neurology, we want to assure you that we have implemented protocols to provide safe and quality care to our patients, while protecting our patients, physicians and staff.
Inappropriate antipsychotic use in patients with #Parkinsons disease can lead to serious complications, including sudden death. Drs. Kevin Kyle & Jeffrey Bronstein discuss the causes of increased risk of #death associated with neuroleptics.
https://www.prd-journal.com/article/S1353-8020(20)30708-2/fulltext
Grand Rounds on Wednesday, 9/30 will feature Dr. Keith Vossel, Director of the UCLA Easton Center for Alzheimer's Research and Professor of Neurology. Dr. Vossel will present "Epileptic Activity in Alzheimer's Disease: Causes and Clinical Relevance" @ 9am.
The optic nerve becomes taut during adduction beyond a certain angle in healthy people and patients with primary open angle glaucoma (POAG), but only retracts the globe in POAG.
In this research study, Dr. Joseph Demer and others utilized #MRI to investigate this difference.
https://www.tandfonline.com/doi/full/10.1080/02713683.2020.1817491
TANDFONLINE.COM
Adduction-Induced Strain on the Optic Nerve in Primary Open Angle Glaucoma at Normal Intraocular Pressure
In patients with #stroke & patent foramen ovale, the RoPE Score has been proposed as a method to estimate the probability that a PFO is causally-related to the stroke. Here, Dr. Jeffrey Saver & others study the RoPE-estimated PFO-attributable fraction & the effect of closure.
https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.029350?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
Recognizing the signs of stroke in an acute setting is challenging. This practical framework was outlined by Dr. Fabien Scalzo & others to create a decision support system using #ArtificialIntelligence that supports emergency department providers in stroke diagnosis.
https://journals.sagepub.com/doi/10.1177/1756286420938962?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed&
Patients with acute ischemic #stroke can be evaluated by multimodal MR imaging, as found in this study by Drs. David Liebeskind, Sidney Starkman, Latisha Sharma, Neal Rao, Jason Hinman, May Nour, Mersedeh Bahr Hosseini, Radoslav Raychev, Doojin Kim, and Jeffrey Saver.
https://www.strokejournal.org/article/S1052-3057(20)30689-3/fulltext
Immediate emergency care with accurate diagnosis of CT images is crucial for dealing with a hemorrhagic #stroke.
In this paper, Drs. David Liebeskind & Fabien Scalzo propose a deep learning framework to automatically detect and segment hemorrhage strokes in CT #brain images.
https://ieeexplore.ieee.org/document/9210782
"That speaks a little bit to the fact that we should have more patient-centered outcomes and things that patients can report."
Dr. Indu Subramanian was quoted by Medscape Neurology about the use of #telemedicine for #Parkinsons disease.
https://www.medscape.com/viewarticle/938739#vp_2
MEDSCAPE.COM
Telemedicine Feasible and Reliable in Parkinson's Trial
This recent study finds that #COVID19 is associated with a small but significant risk of #stroke. Dr. David Liebeskind and other researchers suggest that aggressive monitoring and early intervention should be pursued to mitigate poor outcomes.
https://journals.sagepub.com/doi/10.1177/1747493020959216?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
JOURNALS.SAGEPUB.COM
Cerebrovascular events and outcomes in hospitalized patients with COVID-19: The SVIN COVID-19 Multinational Registry - James E Siegler, Pere Cardona, Juan F Arenillas, Blanca Talavera, Ana N Guillen, Alba Chavarría-Miranda, Mercedes de Lera,...
Researchers including Drs. David Liebeskind & Jeffrey Saver obcerved an increase in thrombectomy treatment for acute ischemic #stroke following publication of positive clinical trials & US guideline update in 2015, leading to improved functional outcomes.
https://www.strokejournal.org/article/S1052-3057(20)30710-2/fulltext
STROKEJOURNAL.ORG
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The Society of Black Neurologists was founded to foster discussion, mentorship, & camaraderie among Black neurologists.
Nearly two years after its inception, this article including Dr. Charles Flippen outlines the SBN's missions & accomplishments: https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(20)30352-5/fulltext
Nature Immunology published a commentary, “A new cell subtype that confers neuroprotection” by Dr. Rhonda Voskuhl, Professor in the Dept of Neurology. Discovery of an immature immune cell shown to repair optic nerve and spinal cord injury.
https://www.nature.com/articles/s41590-020-00821-0
For the Integrated Center for Neural Repair Seminar, Dr. Irene Lorenzo Llorente and her talk, "Glial Enriched Progenitors: A Novel Cell-Based Therapeutic For White Matter Stroke" on Friday, 11/6.
“One of the most troubling things about #COVID19 is that we have a limited ability to predict how sick a specific individual will get.” - Dr. Daniel Geschwind
Mirage News covered a study led by Dr. Geschwind aiming to identify the role #genetics play in #coronavirus severity & susceptibility.
https://www.miragenews.com/researchers-study-genetics-role-in-covid-19-susceptibility-severity/
The 7th International Symposium on Collaterals to the #Brain is entitled "Virtually Normal: Collaterals for #Stroke in a Global Pandemic" & will occur 11/4-11/5. UCLA Neurology speakers include Drs. Radoslav Raychev, Fabien Scalzo, Jason Hinman, & David Liebeskind.
For more info: http://collateralperfusion.org/
COLLATERALPERFUSION.ORG
Collaterals 2020 – 7th Symposium on Collaterals to the Brain
Collet-Sicard Syndrome is a rare condition characterized by the paralysis of cranial nerves IX, X, XII.
In this report, Dr. Bijal Mehta observes a rare case study of a patient experiencing Collett–Sicard Syndrome after blunt head #trauma.
https://www.mdpi.com/2035-8377/12/3/19
Stroke recovery therapies promote favorable neural plasticity. In this paper, Dr. Steven Cramer looks at advances in #stroke, including activity-based therapies and preclinical #drug studies.
https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.033231?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
Alpha-synuclein (α-syn) is a molecule involved in pathology of #Parkinsons disease. A group of researchers including Dr. Varghese John studied the relationship between behavioral deficits and the over-expression of α-syn in mice.
https://content.iospress.com/articles/journal-of-alzheimers-disease/jad200983
Everyday tasks in social settings require humans to encode neural representations of their spatial locations.
In this study, Dr. Dawn Eliashiv reports that spatial location modulates boundary-anchored neural representations in the medial #temporal lobe.
https://www.nature.com/articles/s41586-020-03073-y
In the "Expert Review of Neurotherapeutics", Dr. Bruce Dobkin published an article assessing the various reasons why statin-associated muscle symptoms are under-diagnosed.
https://www.tandfonline.com/doi/abs/10.1080/14737175.2021.1866988?journalCode=iern20
Although antiretroviral therapy reduced the prevalence of #HIV-associated dementia, milder syndromes persist.
Dr. Andrew Levine contributed to the development of prediction models to help clinicians address #dementia in early stages for Multicenter AIDS Cohort Study participants.
https://journals.lww.com/aidsonline/Abstract/9000/Longitudinal_5_year_prediction_of_cognitive.96501.aspx
COVID-19 is associated with a small risk of #stroke, often with an unknown cause.
In this study by Dr. David Liebeskind, cryptogenic stroke among #COVID19 patients was found to carry a significant risk of early mortality.
https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-021-02075-1
BMCNEUROL.BIOMEDCENTRAL.COM
Stroke etiologies in patients with COVID-19: the SVIN COVID-19 multinational registry
Voltage sensing with genetically expressed optical probes can make large-scale recordings of neuronal activity.
Drs. Guido Faas & Istvan Mody develped a method for a hybrid genetically encodable fluorescent #voltage sensing in #brain cells.
https://www.pnas.org/content/118/6/e2020235118.long
"There's #music therapy where you can take people in later stages of Alzheimer's who are seriously impaired & play music they're familiar with."
Dr. Greg Cole was featured on Health on the use of music #therapy to treat late stages of #Alzheimers disease.
https://www.health.com/condition/alzheimers/tony-bennett-alzheimers-disease
HEALTH.COM
Tony Bennett Has Had Alzheimer’s for More Than 4 Years—But He Hasn't Stopped Performing
Falling is a leading cause of unintentional #injury and can result in devastating #disability and fatality when left undetected and not treated in time. Dr. Francy Shu designed a house-wide #fall detection system.
https://www.nature.com/articles/s41598-021-81115-9
NATURE.COM
An eight-camera fall detection system using human fall pattern recognition via machine learning by a low-cost android box
