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AAHA publications
NEWStat 2020-08
The reason cats get COVID and dogs don’t
Tony McReynolds - 8/5/2020
A couple of Canadian researchers may have figured out why cats get COVID and dogs don’t: a mutation in the gene that provides a vector for the novel coronavirus. While a few noted dogs have tested positive for SARS-CoV-2, the virus that causes COVID-19, no dogs have been diagnosed with COVID-19 to date.
Researchers at Dalhousie University in Halifax, Nova Scotia, published a study in which the authors write: “A single genetic change in the host receptor for the virus inherited in cats, but not dogs, correlates with feline susceptibility.”
In other words, during SARS-CoV-2 infection, the virus targets the angiotensin-converting enzyme 2 protein (ACE2). Dogs have a mutation in their ACE2 that gives them a natural resistance to the novel coronavirus. Cats don’t.
That seems to apply to all cats, large and small: the researchers determined that, along with cats, a number of different feline species—cheetahs, leopards, tigers, and lions—are likely to be susceptible to the virus. So are ferrets.
Dogs, bears, pigs, chickens, and ducks are not.
NEWStat reached out to coauthors Graham Dellaire, PhD, a professor of pathology at Dalhousie University, and Sabateeshan Mathavarajah, a doctoral student in the Department of Biochemistry and Molecular Biology at Dalhousie, to find out more.
NEWStat: In a nutshell, why are cats susceptible to SARS-CoV-2 and not dogs?
Graham Dellaire: Dogs have a mutation in the ACE2 receptor at a single amino acid, one of the building blocks of the ACE2 protein. This single mutation weakens the binding of ACE2 by the spike protein of [SARS-CoV-2], the virus that causes COVID-19.
NEWStat: One of the most frustrating things about COVID and companion animals is that even though less than half a dozen dogs in the world have been officially diagnosed with SARS-CoV-2, pet owners are still worried that their dog could get it. If dogs can contract SARS-CoV-2, why haven’t more dogs tested positive?
GD: Dogs can develop antibodies against SARS-CoV-2 when they’re exposed, but the virus replicates poorly, and they do not transmit the virus to each other or to people. This is not the case in cats, who are largely asymptomatic but easily transmit the virus to other cats.
CANE TOAD WARNING We have already lost one dog to these poisonous frogs. Read more at Edgewoodanimalclinic.net to be aware of threat.
MESSENGER
Edgewood Animal Clinic updated their business hours.
MESSENGER
Edgewood Animal Clinic updated their business hours.
MESSENGER
Edgewood Animal Clinic updated their business hours.
We have had our first week of allowing clients in for their appointment, one person with one pet at a time, with success. We appreciate all your patience and acceptance of our safety precautions during this pandemic.